John S Dick

A gene stemness score for rapid determination of risk in acute leukaemia. Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells. Dick's research program aims to understand how stem cells can be manipulated. The assay involves reconstituting immune deficient SCID mice with either normal human bone marrow or cord blood, or with cells from patients with genetic deficiencies or leukemia. In acute myeloid leukemia, only leukemic stem cells can initiate the disease and we have little understanding of which normal cells become transformed in the initiation of leukemia.



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John S Dick
John S Dick

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A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns. Allogeneic human double negative T cells as a novel immunotherapy for acute myeloid leukemia and its underlying mechanisms. This model has transformed the study of both normal and leukemic human blood systems. Without an understanding of how they are different, the mechanism by which the leukemic process alters the development of the normal blood system will never be understood. Until now, this process has always been a mystery.
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